BDBM50262939 2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}phenyl)-5-(trifluoromethyl)-4(3H)-quinazolinone::CHEMBL476323

SMILES Cc1nc2cccc(c2c(=O)n1-c1ccc(OCCCN2CCCC2)cc1)C(F)(F)F

InChI Key InChIKey=DDDZBLNULGDPGA-UHFFFAOYSA-N

Data  7 KI  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50262939   

TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  0.531nMAssay Description:Displacement of [125I]Iodoproxyfan from human recombinant histamine H3 receptor by Competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]N-alpha-Methylhistamine from human recombinant H3 receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  6.80nMAssay Description:Binding affinity to recombinant human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Tsukuba Research Institute

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataKi:  33nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from rat histamine H3 receptor expressed in HEK293 cells coexpressed with CRE-beta-lactamaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Bioprojet-Biotech

Curated by ChEMBL
LigandPNGBDBM50262939(2-Methyl-3-(4-{[3-(1-pyrrolidinyl)propyl]oxy}pheny...)
Affinity DataIC50:  1.70nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed